This test is used to investigate cardiac or skeletal muscle pathology. About 2 of creatine is converted into creatinine daily.
Serum ck concentrations are reflective of muscle mass causing males to have higher concentrations than females.
Ck levels normal. For females normal levels of creatine kinase range between 90 to 140 units per liter u l of blood. Creatine the precursor for creatinine is synthesized in the liver. Ck levels are around 70 higher in healthy african americans compared to people of european descent.
Other tissues such as kidney have low levels of enzyme activity. Troponin levels can take 10 14 days to return to normal. The upper normal limit for men is anywhere from 200 to 395 u l 3 4 6 8 ukat l and for women it s up to 207 u l 3 52 ukat l 3 4 5.
Normally the laboratory provides total ck levels. Some people with a muscular build also have higher levels of ck. Normal ranges are 24 170 units litre in women 24 195 in men.
Chemical pathology notes creatine kinase ck is found in cardiac and skeletal muscle and brain. African americans naturally have higher levels of ck. Ck activity is greatest in striated muscle mm isoenzyme heart tissue mb isoenzyme and brain bb isoenzyme.
This means that if a patient has a 2nd heart attack 2 days after the first an elevated ck mb level can indicate a 2nd mi. Normal values at rest are usually between 60 and 400 iu l where one unit is enzyme activity more specifically the amount of enzyme that will catalyze 1 μmol of substrate per minute under specified conditions temperature ph substrate concentrations and activators this test is not specific for the type of ck that is elevated. The clinician must be aware of the the rare false positives provided by macro ck 1 and macro ck 2.
Normal serum ck is predominantly the ck mm isoenzyme. Normal creatinine levels tend to vary with age. In a normal healthy individual creatinine is excreted from the.
For males normal levels of creatine kinase range between 38 to 174 units per liter u l of blood. Strenuous exercise recent surgery and certain medicines may make your ck levels higher than normal. A heparinised plasma is required.
The same principle is related to myocardial instrumentation. Normal ranges of creatine kinase are as follows.