39 308 u l ck female normal. Levels ck male normal.
There are 3 sub units.
Ck mb levels in mi. They also concluded that 100 of the patients had troponin i positive and 0 had troponin i negative cases 8. Ckmb 5 0 μg l. The ck mb isoenzyme which has a molecular mass of approximately 87 kilodaltons accounts for 5 to 50 of total ck activity in myocardium.
Cautions discusses conditions that may cause diagnostic confusion including improper specimen collection and handling inappropriate test selection and interfering substances. 5 25 iu l myocardial infarction. Medical literature commonly states that ck mb levels become elevated in 4 to 6 hours peak at 10 to 24 hours and return to normal within 3 to 4 days after an acute myocardial infarction.
Ck mb ck relative index is only useful when there is an elevation of both the total ck and the ck mb levels. For detection of myocardial infarction changes in serum ck and its heart tissue mb isoenzyme have been largely replaced by the more cardiac specific nonenzymatic markers cardiac troponin i or t. For example patients with elevated troponin levels but negative creatine kinase mb ck mb values who were formerly diagnosed with unstable angina or minor myocardial injury are now reclassified.
The ck mb level is helpful to quantify the level of muscle damage in mi. If it has been 48 hrs an elevated ck mb could indicate further myocardial injury. The peak ctni at 24 h after onset of chest pain was 1 3 μg l peak ckmb 11 5 μg l and returned to normal 3 days after the event ctni 0 6 μg l.
If it is 5 is suggestive of the cardiac source cardiac muscle damage. Ck mb first appears 4 6 hours after symptom onset peaks at 24 hours and returns to normal in 48 72 hours. Patient 9 was hospitalized january 4 10 2000 for a nstemi non q wave mi per chart documentation and negative adenosine stress test.
Ck mb total ck ratio improves the specificity of ck mb for myocardial infarction. Cardiac troponins troponins t i c are regulatory proteins found in striated and cardiac muscle. 26 192 u l ck mb normal.
Levels should be 2x the. Ck mb is a more sensitive marker of myocardial injury than total ck activity because it has a lower basal level and a much narrower normal range. Raised cpk mb 24iu l and 5 patients had cpk mb within normal range 24iu l which was highly significant.
In skeletal muscle by contrast it normally accounts for 1 ck mm being the dominant form though the percentage can be as high as 10 in conditions reflecting skeletal muscle injury and regeneration eg severe exercise muscular dystrophy polymyositis. Its value in the early and late 72 h diagnosis of acute mi is limited.